Thank you! Hmmm I am excited about the possibility for these therapies, especially in the scope of modular adjustments turning genes on and off without more permanent/unwanted changes. Time will tell.

Back to your initial post. I am intrigued by the TERT and follistatin, would love to see this study replicated. The other paper you mentioned with the multi use cocktail was also compelling, but I thought it was odd they didn’t include a longevity specific arm. I suppose that wasn’t the scope of their intended study, seems like pretty low hanging fruit though. I don’t wanna get too cynical, but I wonder if they DID try a longevity side and things didn’t work out too well? Either way, that should definitely be a follow up study.

I have yet to give those papers a thorough read, but the follistatin one made me think of another version of gene therapy where the clinicians claim their plasmid vector of transfer allows all changes to be reversed.

https://minicircle.io/wp-content/uploads/2024/04/fstpreprint.pdf

My genomics knowledge is certainly lacking, but what are your thoughts on viral vs. plasmid derived gene therapies?