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Cake day: July 12th, 2023

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  • Phages are pretty cool, but bacteria do develop phage resistance as well. Phages also can evolve to evade those resistances, in a co-evolutionary battle, but also Phages can still be seen as antigens to our own body.

    A recent case-study: https://www.upmc.com/media/news/021424-phage-therapy

    To avoid reading the whole article: Antibiotics no-longer worked for a patient in 2020 that developed an infection after needing immunosuppression for treatment of an autoimmune condition, so they tried phage therapy.

    quote from the phage treatment section:

    Within 24 hours of receiving phage therapy, the patient’s blood infection had resolved and she could go home, where she continued the phage and antibiotic combination. She developed a few short-lived breakthrough infections, which indicated the bacteria was getting around the therapy, so the researchers found an additional phage that targeted her bacteria.

    With the addition of the new phage, the patient was blood infection-free for four months and able to travel out of state for a for a family beach vacation.

    However, just over six months after starting phage therapy, the blood infection returned, and the phage-antibiotic combination was thought to be no longer effective. The patient died in 2022.

    In order to learn why the infections recurred despite the combination being previously effective, laboratory testing revealed that the patient’s immune system had likely activated in a way that blocked the phages from attacking the bacteria.

    I’m not disagreeing with the benefits of Phage Therapy, just that it isn’t likely a magic solution all on it’s own, and can still suffer similar resistance issues as antibiotics have. I’m a fan of multipronged attack vectors, to reduce the chance of developing progressive resistances (ie. wipe out the whole colony), and the more tools we have for that, the better.



  • It’s more a joke. At this point ISPs really should be designated a telecom.

    But, if Chevron Deference is the reason it’s on hold, that’s not likely to change until either the legislature passes something to say otherwise, or the supreme court swings the other way/toward normalcy. Which, if Harris wins this election and next election, there is a reasonable chance at. Other than their bitterness, some of the oldest and worst on the supreme court are just hanging on until a conservative takes the executive branch again.

    Edit: good reason to get out and vote. Not just ensure Trump doesn’t win, but also need the Senate to approve supreme court replacements. Otherwise conservatives will just hold up nominations for 4-8 years until they can nominate someone like Alito or Thomas.

    Edit Edit: Additional plea to get out and vote for Senators: even if Trump does win, if conservatives don’t hold the senate, he can’t put another Alito or Thomas on the court. I don’t think dems have the backbone to indefinitely block an appointment, but they would approve someone more moderate probably, that can be pursueded on matters such as net neutrality, abortion.



  • I believe I saw a story about a Russia state media person proposing using tactical nukes on their own territory. I don’t think they actually would, but Russia may… Let the enemy group up in your own territory, and nuke it… other than humanitarian concerns for their own citizens, other countries ability to complain would be dulled if they were nuking their own internationally recognized territory.

    Honestly, probably a great tactic to act as a deterrent in future wars (such as with the US).

    I’ve caved by the end of this message… no sane person would, but I wouldn’t call Russia’s current government sane.


  • Good distinction. In my younger days when Anime choices were slimmer, I enjoyed Sailor Moon, and Nanoha. Nowadays, I can’t remember the last time I watched a transforming Magical Girl anime, I much prefer the later. Fantasy settings, magic, Isekai (…which are abundant nowadays…bordering on too abundant, but I don’t get tired of them because magic).

    Edit: BTW, not a knock on Nahoha. As I recall, great series, though only gave it a once through. … Now that I’m thinking about Magical Girl anime, also remember Figure 17 I think it was called… still have music from it’s OST on my playlist; had some good battle music, and calming/relaxing music.



  • Just show up for the Sept 10th debate you already agreed to. ABC, don’t cave to any of his weird demands/temper tantrum; just do the debate as agreed, and if he doesn’t show, that’s fine too.

    People aren’t going to want to watch three debates of your dumb ass in a single month. One debate is sufficient in September. If you both agree on it, one in October to keep it fresh in people’s minds are also fine, though not necessary. Everyone knows Trump already, this is really just a chance for undecideds, or wall sitters to get to know Harris.



  • knowing anything about women’s health because it’s “yucky”

    Can we just rename Tampons for them, to “Jesus Sticks”, and when they have to have an uncomfortable conversation, they can just pull one out and say “You need Jesus”? Or when asking someone for one, someone can proudly proclaim “I need Jesus” to their friends.

    I’ve gotten the seriousness out in other comments; I just had the thought, and had to share it somehow, somewhere.

    They’ve done a good job making menstruation ‘yucky’; the majority of women I know have at some point apologized to me after periods come up in group or private conversations. It’s just a period, nothing to be ashamed of.



  • Truck_kun@beehaw.orgtoMemes@lemmy.mlFirefox + Ublock = 👑
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    3 months ago

    For others, I set up uBlock at minimum.

    For myself uBlock + uMatrix.

    If on a computer need more security uBlock + uMatrix + NoScript.

    uBlock and uMatrix can block scripts, but I find NoScript’s fine grain control to be user friendly. Makes it a pain to browse the web though, until you setup each of your normal sites.





  • I only learned about quarantine the other day. Specifically I think it was me sending short messages that make sense when emailing yourself, like a photo with no body text, or just “test”.

    Going through there, found my Gmail, my personal domain, and my @fastmail domain all going there until I approved one of them.

    I had my personal domain on a lifetime mxroute account before this, but wasn’t using it. Made the move to fastmail to seriously move away from Google. I have my purchase ebooks backed up there, and they could close my account someday because of it, even if it’s a personal backup of purchased items and not sharing with others.

    Also making a wasabi account and using rclone to sync my library, so can move away on that front too. though Wasabi has a perfectly usable web interface. i have my reasons for choosing them over backblaze.



  • I’m a recent fastmail user:

    Pros: First off, they put me on a 30 day trial, so had a full 30 days to try out; I would suggest trying their trial as one of your first things.

    I do love that I can make so many aliases for different email things.

    I do love I can add an API key to my bitwarden account to auto-generate email masks for things: https://bitwarden.com/blog/use-bitwarden-to-generate-email-aliases-with-fastmail/

    Offer’s a reasonably priced family plan for up to 6 users (50 GB per user - after using Gmail from day one, including non-email storage, my Gmail is only up to 35 GB), and they have annual plan options which give you a discount over monthly for a better deal.

    Has a calendar feature, and notes, for which I am putting stuff I used to text to myself, or message to my wife on discord.

    Use multiple of my own domains (purchases elsewhere), and just set the nameservers to FastMail, and they handle setting up everything for modern email like DKIM, DMARC, and stuff. Though you are not obligated to purchase a domain, they have many you can choose from. They allow you to use a ton of custom domains (where as some other providers allow like 3, 10, or 30, depending on your plan).

    They have an import feature from your old mail accounts. I did not try it, as I decided to start fresh. I’m trying to move away from gmail incase they lock me out someday, but my account is in good standing, and I have access to everything there as storage; just proactively moving all my important accounts over to my own domains.

    I’ll put this at the end as it is a pro or con depending on your outlook: I trust FastMail to not use my data like google, and am okay with our business relationship. Because of this, I am okay with my data not being so hard locked down that FastMail is able to restore access/help users getting locked out of their accounts. For a true End-to-End encrypted option, I question if that recovery would be possible (which can be a good thing, if your purpose is protecting your data, even from warrants/court orders/subpoenas); they may have recovery keys, but what if you lost those?

    Con: Found out after my trial ended, that when I email my work, my emails go to Quarantine. Our work uses Microsoft Outlook, and they have a quarantine feature that keeps stuff from hitting even the spam folder; my work has phishing set to ‘aggressive’, which is what is quarantining my emails. Once i passed one email through quarantine, i’m recieiving them fine now. Also if the user adds the email to their contacts list.

    After looking around, this appears to be an ongoing issue with microsoft from fastmail emails. You cant email email the recipient to inform them of the quarantined email, because all emails are quarantined. Not a deal breaker, as it’s microsoft’s doing, not FastMail, but still annoying, especially if you have to tell them to add you as a contact first. May get better after your domain builds some reputation with their servers, I don’t really know yet. More of a reason for me to avoid recommending Microsoft as an email provider; quarantine is great for protecting users, but unless you have an IT person regularly checking and approving quarantined emails, it is so easy to miss legitimate emails from clients. I’ve also seen an email from my gmail account in the quarantine system, so it can catch up even big email providers.

    A lot of people recommend https://tuta.com/ as a more privacy conscious option, and if I did decide to leave FastMail, they are probably what I would switch to. They do have a free email. Tuta also has family options, which can be more generous storage wise depending on your plan, but their family option appears to just be pay the full price of your plan for each user to add them to your family plan, and Tuta (at least from their pricing page), only has monthly as an option, no discounts for commitments.

    For fastmail, I pay $132/year ($11/month equivalent - actually $14/month if on a monthly plan) for 50 GB for 6 users (300 GB total), For Tuta it appears to be €3/user/month for 20GB, or €8/user/month for 500 GB (so for 2 users, you are either paying €6 or €16). Ultimately I found FastMail to be a better choice for me. If you switch to business, they do have a €6/user/month option for 50 GB /user, which would be €12/month, so comparable to FastMail’s family plan if you only have 2 users, but less comparable if you need more than 2 users. Due to tuta’s pricing structure, you could just get each user the plan they need (not sure if that requires separate accounts, or if can be done on a family plan, which does have domain sharing implications, but maybe everyone wants their own domains).

    My recommendation would be to make a FastMail trial, make a free tuta account, and try both for a month, then make your decision.