Why do those with autism avoid eye contact? Imaging studies reveal overactivation of subcortical brain structures in response to direct gaze
www.sciencedaily.com
Individuals with autism spectrum disorder often find it difficult to look others in the eyes as they find eye contact uncomfortable or stressful. Now a study has shed light on the brain mechanisms involved in this behavior.

Direct gaze - that is, eye contact with another person - causes the subcortical system to overload, and the parts of the brain that deal with arousal and calming are failing to strike a balance. The end result is that direct eye contact triggers a physiological response which makes it physically uncomfortable to maintain eye contact.